Stem cell transplant for multiple myeloma


Multiple myeloma is broadly considered an incurable cancer of plasma cell which one of the  component of blood. However, the rapid pace of research in stem cell transplant for multiple myeloma is changing the landscape of its treatment and emerged as only  potential curative option.

Study of both autologous stem cell transplant and allogeneic stem cell transplant approaches for multiple myeloma  has suggested . High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (HCT) remains best treatment strategy, and the inclusion of novel immunomodulators and proteasome inhibitor to induction regimens improves response rates and increases overall survivals.  Bortezomib- and lenalidomide-based combination chemotherapy regimens have become the standard induction myeloma therapy.

stem cell transplant for multiple myeloma

what is the present state of stem cell transplant for multiple myeloma?

Stem cell transplant for multiple myeloma is a potentially curative transplant option.  When patients undergo stem cell transplant for multiple myeloma after novel combination regimens, their response rates are further improved.  Despite these recent major improvements, multiple myeloma remains incurable and long-term survival appears elusive.  Due to a potential graft-vs-myeloma effect.


what is the future of stem cell transplant for multiple myeloma?

Initial attempts have been hampered by the high transplant-related complications because of high toxicity of chemotherapy.  allogeneic transplant approaches with reduced-intensity induction chemotherapy have been utilized, although they are subject to continued disease progression and relapse following transplantation.

Recent research efforts have shifted to the use of a tandem autologous-allogeneic stem cell transplant for multiple myeloma approach.  The long-term follow-up of this new strategy is awaited.but further research and the development of more multimodal therapeutic approaches is warranted to cure this disease.


Final say for stem cell transplant for multiple myeloma-

Multiple myeloma has been the most intractable hematological disease for many years.The introduction of high-dose chemotherapy with autologous stem-cell transplantation and the availability of molecular-targeted novel agents such as immunomodulatory drugs and proteasome inhibitors have significantly improves results of treatment.

Continued research activity focuses on the strategies to improve outcomes of stem cell transplant for multiple myeloma by incorporation of tandem autologous-allogeneic transplantation, novel conditioning regimens, and the use of consolidation and maintenance therapy.

In brief stem cell transplant for multiple myeloma is an expensive and risky option and may or may not give 100%  cure , but It definitely gives an opportunity for the patients to live a healthy and productive life  .

 

How do i find out the latest treatment options for multiple myeloma?

As the research for treatment of multiple myeloma is done accross the globe and progressing at a rapid pace , Patient-Help.com cunnects multiple myeloma patients with experts across the globe . Patients can compare the available latest treatment options free!

 

Summary

High-dose chemotherapy followed by autologous hematopoietic stem cell transplant for multiple myeloma remains an integral component of upfront treatment strategy, and the inclusion of novel immunomodulators and proteasome inhibitor to induction regimens improves response rates and increases overall survivals. Despite these recent major improvements, multiple myeloma remains incurable and long-term survival appears elusive.  Due in part to a potential graft-vs-myeloma effect,

Allogeneic stem cell transplant for multiple myeloma is a potentially curative transplant option.  However has high transplant-related mortality.   Recent research efforts have shifted to the use of a tandem autologous-allogeneic stem cell transplant for multiple myeloma approach.  The long-term follow-up of this new strategy is awaited.

In brief stem cell transplant for multiple myeloma is an expensive and risky option and may or may not give 100%  cure , but It definitely gives an opportunity for the patients to live a healthy and productive life  .

 

References


Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification ofMyeloma and Risk-Adapted Therapy (mSMART) consensus guidelines 2013.

Mikhael JR, Dingli D, Roy V, Reeder CB, Buadi FK, Hayman SR, Dispenzieri A, Fonseca R, Select item 232904393.

Multiple myeloma: future directions in autologous transplantation and novel agents.

Hari PN, McCarthy PL.

Current therapeutic strategy for multiple myeloma.

Suzuki K.

Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group.

Fernández de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH, Hajek R, San

Multiple myeloma : recent progress in diagnosis and treatment.

Chou T.